gene 2,169 words KG: THAP1 2026-03-28
kind:genesection:genesstate:publishedtopic:parkinsonstopic:dystonia
Contents

THAP1 Gene

🧬 Gene Info
Gene SymbolTHAP1
Full NameTHAP Domain Containing 1
Chromosome8p21.2
Protein TypeTranscription Factor
Functionencodes a zinc finger transcription factor belonging to the THAP (THANATOS-associated protein) family.
Primary ExpressionBrain, testis, blood, endothelium
Amino Acids342 aa
Exons11
UniProt IDQ9NVX4
NCBI Gene ID55145
GeneCardsTHAP1
Human Protein AtlasTHAP1
Associated DiseasesAls
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: associated_with
TOR1A Gene
gene · KG edge: associated_with
GNAL — Gαolf Subunit
gene · KG edge: associated_with
GCH1 Gene
gene · KG edge: associated_with

Knowledge Graph (8 edges)

THAP1 associated_with ANO3
THAP1 associated_with GNAL
THAP1 associated_with TOR1A
THAP1 contributes_to ANXIETY
THAP1 contributes_to DEPRESSION
THAP1 associated_with Als
THAP1 contributes_to Actin
GCH1 associated_with THAP1