| Gene Symbol | ANO3 |
| Protein Type | Channel |
| Function | is a gene encoding a calcium-activated chloride channel protein. |
| Primary Expression | the basal ganglia, cortex, and cerebellum, consistent with its r |
| Amino Acids | 982 aa |
| Ensembl ID | ENSG00000162836 |
| GeneCards | ANO3 |
| Human Protein Atlas | ANO3 |
| Eight transmembrane domains | Spanning the plasma membrane |
| Calcium-binding domain | Intracellular C-terminus contains calcium-binding sites |
| Phospholipid scramblase domain | May facilitate lipid movement across membrane |
| Dimerization capability | Functional channels form as homodimers or heterodimers |
| Striatum | High expression in medium spiny neurons (MSNs) |
| Globus pallidus | Both internal and external segments |
| Substantia nigra | Pars compacta and pars reticulata |
| Associated Diseases | Als, Alzheimer, dementia, neurodegeneration |
| Interactions | RBFOX1 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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