protein

Actin

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Actin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1588Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Actin
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Atherosclerosis, Cancer
Interactions	FUS, TAX1BP1, ALS, TOLLIP, G3BP1, ULK1
KG Connections	1453 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Actin["Actin"] -->|"interacts"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -->|"interacts"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -->|"interacts"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style Frontotemporal_Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Actin["Actin"] -->|"interacts"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    FUS["FUS"] -->|"interacts"| Actin["Actin"]
    style FUS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TAX1BP1["TAX1BP1"] -->|"interacts"| Actin["Actin"]
    style TAX1BP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"interacts"| Actin["Actin"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TOLLIP["TOLLIP"] -->|"interacts"| Actin["Actin"]
    style TOLLIP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    G3BP1["G3BP1"] -->|"interacts"| Actin["Actin"]
    style G3BP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Actin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (447)

Target	Relation	Type	Str
Dementia	interacts_with	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Dementia	activates	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Als	activates	disease	0.60
Als	contributes_to	disease	0.60
Als	transports	disease	0.60
Ischemia	regulates	disease	0.60
Als	causes	disease	0.60
Cancer	therapeutic_target	disease	0.60
Fibrosis	regulates	disease	0.60
Cancer	interacts_with	disease	0.60
Glioblastoma	associated_with	disease	0.60
Cancer	phosphorylates	disease	0.60
Als	phosphorylates	disease	0.60
Aging	interacts_with	disease	0.60
Aging	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Parkinson	associated_with	disease	0.60
Neurodegeneration	activates	disease	0.60
Ischemia	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Tauopathy	stabilizes	disease	0.60
Alzheimer	stabilizes	disease	0.60
Parkinson	activates	disease	0.60
Aging	associated_with	disease	0.60
Cancer	regulates	disease	0.60
Als	regulates	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	associated_with	disease	0.60
Als	expressed_in	disease	0.60
Cancer	activates	disease	0.60
Aging	degrades	disease	0.60
Ischemia	associated_with	disease	0.60
Schizophrenia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Depression	activates	disease	0.60
Migraine	activates	disease	0.60

Incoming (1141)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
FUS	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
APOA1	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
AMPK	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
MAO	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SPHK1	activates	gene	0.60
TFEB	activates	gene	0.60
ATG	activates	gene	0.60
DEMENTIA	activates	gene	0.60
VCP	activates	gene	0.60
TBK1	activates	gene	0.60
ALS	activates	gene	0.60
DNA	activates	gene	0.60
OVERVIEW	activates	gene	0.60
MTOR	activates	gene	0.60
CHMP2B	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PTEN	activates	gene	0.60
PINK1	activates	gene	0.60
VALOSIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Actin

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

williams-syndrome

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Oligodendrocytes

Blood-Brain Barrier Dysfunction in Neurodegeneration

ncam2

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

CNTN6 — Contactin 6

dendritic-spines

CNTN4 — Contactin 4

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Synaptic Vesicle Trafficking in Parkinson's Disease

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

CNTN3 — Contactin 3

MACF1 — Microtubule-actin crosslinking factor 1