gene 1,866 words KG: TOMM40L 2026-03-26
kind:genesection:genesstate:published
Contents

TOMM40L — Translocase of Outer Mitochondrial Membrane 40 Like

🧬 Gene Info
Gene SymbolTOMM40L
Full NameTranslocase of Outer Mitochondrial Membrane 40 Like
Chromosome1q21.3
FunctionThis process is critical for mitochondrial biogenesis and function:
Molecular Weight43 kDa
Amino Acids384 aa
Exons9
Ensembl IDENSG00000146215
GeneCardsTOMM40L
Human Protein AtlasTOMM40L
TOMM20Receptor protein that recognizes mitochondrial targeting signals
TOMM22Central receptor component
TOMM40Channel-forming subunit (TOMM40L is a paralog)
TOMM5Small accessory subunit
TOMM7Accessory subunit for complex stability
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (14)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses