gene 1,771 words KG: TREML2 2026-03-24
kind:genesection:genesstate:published
Contents

TREML2 — Triggering Receptor Expressed on Myeloid Cells-Like 2

🧬 Gene Info
Gene SymbolTREML2
Full NameTREML2 — Triggering Receptor Expressed on Myeloid Cells-Like 2
AliasesTriggering Receptor Expressed on Myeloid Cells-Like 2
Chromosome6p21.1.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localizationpatterns [6]. These database references provide foundational information for researchers investigating TREML2 function a
NCBI Gene IDSearch NCBI
Ensembl IDENSG00000162009
GeneCardsTREML2
Human Protein AtlasTREML2
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (18)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.74

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses