Contents

ABCA7 Lipid Transport and Microglial Phagocytosis AD Causal Chain

🔬 Protein Info

Gene Symbol	ent-gene-0cd1e1e5
Phospholipid and cholesterol efflux	ABCA7 facilitates the transport of phospholipids and cholesterol to lipid acceptors, particularly APOE
APOE lipidation	ABCA7 is critical for the lipidation of APOE particles, which is essential for their function in Aβ clearance and synaptic repair
Membrane lipid homeostasis	ABCA7 regulates the lipid composition of cellular membranes, particularly in lipid rafts
Microglia	Highest expression in microglia, particularly in perivascular and brain border-associated macrophages
Astrocytes	Moderate expression in astrocytes
Neurons	Lower expression, primarily in certain neuronal populations
Oligodendrocytes	Low expression
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph