| Gene Symbol | blood |
| Minimally invasive | Less invasive than cerebrospinal fluid collection via lumbar puncture |
| Primary care applicability | Can be used in routine clinical settings without specialized infrastructure |
| High diagnostic accuracy | AUC values exceeding 0.90 for distinguishing AD from controls |
| Cost-effective | Significantly cheaper than PET imaging or CSF analysis |
| Amyloidosis cohort | Patients with confirmed systemic AL (immunoglobulin light chain) and ATTR (transthyretin) amyloidosis |
| Control cohort | Healthy individuals and patients with non-amyloid-related polyneuropathy |
| AD cohort | Confirmed Alzheimer's disease patients for comparison |
| Measurements | Serum p-tau181 and p-tau217 using certified immunoassays |
| p-tau217 superiority | p-tau217 better discriminated ATTR from controls than p-tau181 |
| Polyneuropathy independence | p-tau217 was elevated even in ATTR patients without peripheral neuropathy |
| Cardiac involvement | Patients with cardiac ATTR showed higher p-tau levels |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |