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mechanism 2,341 words KG: synaptic_dysfunction 2026-04-01
kind:mechanismsection:mechanismsstate:publisheddisease:cbs
Contents

Synaptic Dysfunction in Corticobasal Syndrome

⚙ Mechanism Info
NameSynaptic Dysfunction in Corticobasal Syndrome
SummaryComprehensive mechanisms of synaptic dysfunction in CBS: single-cell transcriptomics, electrophysiology, transcallosal disinhibition, comparison with AD/PSP, and therapeutic approaches.
Key Genes/Proteinsprotein_oligomers
Related Diseasesneurodegeneration
Linked Hypotheses2 hypotheses

Knowledge Graph

Related Hypotheses (30)

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Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

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Related Experiments (8)

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clinical · proposed · Score: 0.40

See Also (5)

C3 — Complement Component 3
gene · KG edge: causesNeurodegeneration
disease · KG edge: contributes_toCA2 Pyramidal Neurons
cell · KG edge: causesSynaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 3 hypothesesNeuroinflammation Hypothesis in Alzheimer's Disease
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

synaptic_dysfunction contributes_to neurodegeneration
protein_oligomers causes synaptic_dysfunction

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