| Gene Symbol | ent-gene-257405c9 |
| cGAS (cyclic GMP-AMP synthase) | A DNA-binding enzyme that catalyzes the production of the second messenger cGAMP when activated by double-stranded DNA |
| STING (Stimulator of Interferon Genes) | A transmembrane protein in the endoplasmic reticulum that binds cGAMP and triggers downstream signaling cascades |
| 2008 | Identification of STING (then called MITA) as essential for IFN responses to viral infection |
| 2012 | Discovery that cGAS is the cytosolic DNA sensor that produces cGAMP |
| 2013 | Demonstration that cGAMP is the second messenger produced by cGAS that activates STING |
| 2015 | Recognition of cGAS-STING activation in neurodegenerative diseases |
| 2018-2020 | Development of STING inhibitors for neurological diseases |
| 2020-2024 | Clinical translation of cGAS-STING targeting approaches |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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