mechanism 1,164 words KG: ent-gene-7ab18253 2026-03-31
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:causal-chainstopic:synaptic-protectiontopic:ephrin-signalingtopic:protective-genetics
Contents

EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-7ab18253
Chromosome7q34
FunctionSynaptic plasticity, immune regulation
Primary ExpressionNeurons, astrocytes, microglia
Location7q34
ProteinReceptor tyrosine kinase (976 aa, ~108 kDa)
GWAS SignalProtective (OR 0.88-0.92 per protective allele)
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (11)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90
Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90
CD2AP expression and cognitive decline in AD patients
exploratory · proposed · Score: 0.80
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40