| Gene Symbol | ent-gene-95937963 |
| HSPA1A (Hsp70) | Stress-inducible isoform highly upregulated under proteotoxic stress conditions |
| HSPA8 (Hsc70) | Constitutively expressed "constitutive" Hsp70 involved in protein folding and autophagy |
| HSPA5 (GRP78/BiP) | The master ER chaperone that regulates the unfolded protein response |
| HSPA9 (mortalin/GRP75) | Mitochondrial Hsp70 involved in protein import and mitochondrial quality control |
| HSP90AA1 | Cytosolic, stress-inducible isoform |
| HSP90AB1 | Cytosolic, constitutively expressed "β" isoform |
| HSP90B1 (GRP94) | ER-resident isoform |
| HSP90 (mitochondrial) | Distinct mitochondrial isoform involved in protein import |
| NEFs (HSP110, BAG1-6) | Regulate nucleotide exchange and substrate release kinetics |
| Hsp40/Hsp70 complexes | Form the primary machinery for alpha-synuclein clearance in neurons |
| ERdj proteins (DNAJB9, DNAJC3) | ER-resident J-domain proteins coordinating protein folding |
| Calnexin/Calreticulin | Calcium-dependent chaperones affected in PD |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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