mechanism 2,325 words KG: ent-gene-9f063e98 2026-04-01
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:causal-chaintopic:lrrk2topic:kinasetopic:autophagytopic:parkinson
Contents

LRRK2→Kinase→Autophagy→PD Causal Chain

🔬 Protein Info
Gene SymbolLRRK2
Full NameLRRK2 (Leucine-Rich Repeat Kinase 2)
Chromosome12q12
Protein TypeProtein
FunctionSerine/threonine kinase, GTPase
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
ProteinLeucine-Rich Repeat Kinase 2
InheritanceAutosomal dominant
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Autophagosome Maturation Checkpoint Control
Score: 0.49
Circadian Clock-Autophagy Synchronization
Score: 0.55
Cell-Type Specific TFEB Modulation
Score: 0.48

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (26)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98