| Gene Symbol | ent-gene-69e4f0e3 |
| Protein Family | Pannexin gap junction proteins (PANX1, PANX2, PANX3) - evolutionary distinct from connexins |
| Structure | Heptameric hemichannel (seven subunits) forming a large-pore channel |
| Conductance | ~500 pS when fully opened, allowing passage of molecules up to 1 kDa |
| Regulation | Multiple mechanisms control channel activity including caspase-3/7 cleavage, voltage-gated activation, intracellular Ca2+ changes, and mechanical stress |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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