mechanism 2,540 words KG: ent-gene-9f063e98 2026-04-01
kind:mechanismsection:mechanismsevidence:strongmechanismstate:publishedtopic:parabacteroidestopic:lrrk2topic:gut-brain-axistopic:neuroinflammationtopic:parkinson
Contents

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

🔬 Protein Info
Gene Symbolent-gene-9f063e98
ClassificationBacteroidales > Tannerellaceae > Parabacteroides
Metabolic profileProduces short-chain fatty acids (SCFAs) including acetate and propionate
Anti-inflammatory propertiesKnown to suppress TLR4-mediated inflammation in intestinal epithelial cells
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41

Related Analyses (30)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (22)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98