| Gene Symbol | ent-gene-9f063e98 |
| Armadillo repeats (residues 1-300) | Mediates protein-protein interactions and localization to membranes including the Golgi apparatus and synaptic vesicles |
| Ankyrin repeats (residues 300-500) | Scaffold function for substrate recruitment and complex assembly |
| ROC domain (residues 1335-1510) | GTPase activity that allosterically regulates kinase function |
| COR domain (residues 1510-1840) | Kinase regulation through inter-domain interactions |
| Kinase domain (residues 1875-2300) | Serine/threonine kinase that phosphorylates downstream substrates |
| Neuronal process outgrowth | Regulates dendritic arborization and axon guidance during development |
| Synaptic function | Modulates synaptic vesicle cycling, neurotransmitter release, and plasticity |
| Protein translation | Controls mTOR-mediated protein synthesis pathways |
| Dopaminergic neuron survival | Essential for viability of substantia nigra dopaminergic neurons |
| Mitochondrial dynamics | Influences mitochondrial fission/fusion balance and quality control |
| Substantia nigra pars compacta | Dopaminergic neurons |
| [Cortex](/brain-regions/cortex) | Layer 5 pyramidal neurons |
| Striatum | Medium spiny neurons |
| Cerebellum | Purkinje cells |
| Kidney | High expression in proximal tubules |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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