mechanism 1,584 words KG: ent-gene-5b8aa21c 2026-04-01
PSEN1presenilinAlzheimer's diseasecausal chainamyloidgamma secretaseearly-onset ADautosomal dominant
Contents

PSEN1 Presenilin 1 AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-5b8aa21c
Chromosome14q24.3
FunctionAspartyl protease, gamma-secretase catalytic subunit
ProteinPresenilin 1 (467 amino acids)
InheritanceAutosomal dominant
Age of OnsetTypically 30-60 years (mean ~45)
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (7)

Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90
Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90
Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice
validation · proposed · Score: 0.90
Amyloid plaque load analysis in triple-mutant mouse brains
exploratory · proposed · Score: 0.88
Tet2 expression analysis in aged 2×Tg-AD mouse brains
exploratory · proposed · Score: 0.85

Knowledge Graph (4 edges)

ent-gene-5b8aa21c data_in ad_genetic_risk_loci:PSEN1
ent-gene-5b8aa21c data_in benchmark_ot_ad_answer_key:PSEN1
ad_genetic_risk_loci:PSEN1 data_in ent-gene-5b8aa21c
benchmark_ot_ad_answer_key:PSEN1 data_in ent-gene-5b8aa21c