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mechanism 3,215 words KG: ent-gene-a90f5952 2026-03-26
kind:mechanismsection:mechanismsstate:publishedtopic:synthesistopic:causal-chaintopic:parkinson
Contents

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain

🔬 Protein Info
Gene Symbolent-gene-a90f5952
SummarySynthesis tracing the causal pathway from VPS35 retromer mutations to endosomal dysfunction to alpha-synuclein pathology in Parkinson's disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Microbial Inflammasome Priming Prevention
Score: 0.58Smartphone-Detected Motor Variability Correction
Score: 0.56Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44

Related Analyses (30)

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Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-a90f5952 data_in benchmark_ot_ad_answer_key:VPS35
benchmark_ot_ad_answer_key:VPS35 data_in ent-gene-a90f5952
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