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mechanism 3,254 words KG: Trem2
Contents

microglial-synaptic-pruning-dysregulation

⚙ Mechanism Info
NameTrem2
Key Genes/ProteinsapoE, APOE, C1q
Related DiseasesAd, Alzheimer's_disease, Alzheimer's Disease, Alzheimer's disease pathology, amyloid_clearance
Related PathwaysABCA1/LXR pathway
Linked Hypotheses1 hypotheses

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Related Hypotheses (1)

CX3CR1-Negative Trem2-High Microglial Subset Mediates Female
Score: 0.57

Knowledge Graph (12 edges)

Trem2 activates phagocytic activity
Trem2 modulates neurodegenerative disorders
Trem2 regulates microglial activity
Trem2 biomarker_for Alzheimer's Disease
39308178 are trapped in transition to the fully reactive state without Trem2
Trem2 regulates Disease-Associated Microglia Formation
Trem2 activates SYK/PI3K pathway
Trem2 associated_with Microglial Survival
Trem2 regulates lipid_metabolism
Trem2 inhibits Nf-Κb Signaling

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