Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lipid_metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A mechanism referenced in 1 knowledge graph relationship. Key connections: TREM2_protein (protein) regulates.
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| Name | lipid_metabolism |
| Key Genes/Proteins | APOE, TFEB, Trem2 |
| Related Diseases | Alzheimer_disease |
| Related Pathways | LXR pathway |
| Linked Hypotheses | 8 hypotheses |
Knowledge base pages for this entity
flowchart TD
N0["lipid_metabolism"]
N1["RPS18"]
N1 -->|"participates in"| N0
N2["TMEM55B"]
N2 -->|"modulates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer_disease | dysregulated_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | regulates | gene | 1.00 |
| astrocytes | regulates | cell_type | 0.70 |
| Trem2 | regulates | protein | 0.70 |
| LXR pathway | regulates | pathway | 0.70 |
| TFEB | regulates | gene | 0.70 |
| WAM | activates | cell_type | 0.64 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 1 hypotheses Top: 0.697
lipidomics | 2026-04-16 | 13 hypotheses Top: 0.802
proteomics | 2026-04-16 | 19 hypotheses Top: 0.591
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670
neuroinflammation | 2026-04-14 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CERS2 genetic deletion rescues IL-10 deficiency inflammation | validation | inflammatory bowel disease | 0.850 | 0.00 | IL-10/CERS2 double knockout mi | proposed | N/A |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Validation: Membrane-Nucleation in iPSC Neurons | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism [PMID:40624017] | Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X, | Nat Commun | 2025 | 1 |
| IL-10 constrains sphingolipid metabolism to limit inflammation. [PMID:38383790] | York AG, Skadow MH, Oh J, Qu R, Zhou QD, | Nature | 2024 | 1 |
| PAQR4 regulates adipocyte function and systemic metabolic health by mediating ce [PMID:38961186] | Zhu Q, Chen S, Funcke JB, Straub LG, Lin | Nat Metab | 2024 | 1 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Resibufogenin protects against atherosclerosis in ApoE(-/-) mice through blockin [PMID:40258472] | Xiaoyang C, Yijun C, Chenguang Z, Wanyin | J Adv Res | 2026 | 0 |
| High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402] | Du Y, Borné Y, Samuelsson J, Glans I, Hu | Neurology | 2026 | 0 |
| Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Fo [PMID:41410044] | Zhang J, Yu L, Yang W, Cao L, Wang X et | Circulation | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808] | Acharya A, Ambikan AT, Neogi U, Lamberty | Res Sq | 2026 | 0 |
| Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475] | Dang TN, Ghosh B, Panta PR, Taylor JM, K | J Lipid Res | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier f [PMID:41856194] | Ma X, Liu Q, Mai K, Zhang Y | Int J Biol Macromol | 2026 | 0 |
| HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381] | Hjæresen S, Gramkow ET, Zhang M, Svennin | Prog Neurobiol | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzhe [PMID:41890452] | Arriaga P, Vianna K, Montez C, Panariell | Cureus | 2026 | 0 |
| Genetic modifiers of APOE-ε4-associated cognitive decline. [PMID:41720779] | Contreras AG, Walters S, Eissman JM, Arc | Nature communications | 2026 | 0 |
| Protective ApoE variants support neuronal function by effluxing oxidized phospho [PMID:41338186] | Ralhan I, Do AD, Bae JY, Feringa FM, Cai | Neuron | 2026 | 0 |
| Metabolic abnormalities and reprogramming in cats with naturally occurring hyper [PMID:39499136] | ["Li Q", "Homilius M", "Achilles E", "Ma | ESC heart failure | 2025 | 0 |
| Reduced circulating sphingolipids and CERS2 activity are linked to T2D risk and [PMID:39792658] | Khan SR, Ye WW, Van JAD, Singh I, Rabiee | Science advances | 2025 | 0 |
| Very long-chain fatty acids drive 1-deoxySphingolipid toxicity. [PMID:41298489] | ["Majcher A", "Karsai G", "Yusifov E", " | Nature communications | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
archived · Rounds: 2 · Score: 0.64 · 2026-04-28
closed · Rounds: 4 · Score: 0.76 · 2026-04-28
closed · Rounds: 4 · Score: 0.59 · 2026-04-27
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
Hypotheses and analyses mentioning lipid_metabolism in their description or question text
Score: 0.610 · neurodegeneration · 2026-04-04
## Mechanistic Overview APOE4-Lipid Metabolism Correction starts from the claim that modulating APOE within the disease
Score: 0.525 · neurodegeneration · 2026-04-21
## Mechanistic Overview TREM2 Epigenetic Window for Microglial Lipid Metabolism starts from the claim that modulating TR
Score: 0.455 · neurodegeneration · 2026-04-27
Target sphingomyelin phosphodiesterase or ceramide kinase to restore membrane fluidity and improve phagocytic function t
Score: 0.000 · unknown disease · 2026-04-28
APOE4 creates cell type-specific vulnerabilities, with recent evidence showing PICALM AD risk alleles cause aberrant lip