Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lipid_metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A mechanism referenced in 1 knowledge graph relationship. Key connections: TREM2_protein (protein) regulates.
| Name | lipid_metabolism |
| Key Genes/Proteins | APOE |
| Related Diseases | Alzheimer_disease |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
flowchart TD
N0["lipid_metabolism"]
N1["RPS18"]
N1 -->|"participates in"| N0
N2["TMEM55B"]
N2 -->|"modulates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer_disease | dysregulated_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | regulates | gene | 1.00 |
| astrocytes | regulates | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte APOE4-Specific Lipid Metabolism Correction | 0.479 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
| Sphingolipid Metabolism Reprogramming | 0.443 | neurodegeneration | 4R-tau strain-specific spreading pattern |
| APOE4-Lipid Metabolism Correction | 0.425 | neurodegeneration | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.595
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism [PMID:40624017] | Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X, | Nat Commun | 2025 | 1 |
| IL-10 constrains sphingolipid metabolism to limit inflammation. [PMID:38383790] | York AG, Skadow MH, Oh J, Qu R, Zhou QD, | Nature | 2024 | 1 |
| PAQR4 regulates adipocyte function and systemic metabolic health by mediating ce [PMID:38961186] | Zhu Q, Chen S, Funcke JB, Straub LG, Lin | Nat Metab | 2024 | 1 |
| Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier f [PMID:41856194] | Ma X, Liu Q, Mai K, Zhang Y | Int J Biol Macromol | 2026 | 0 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Resibufogenin protects against atherosclerosis in ApoE(-/-) mice through blockin [PMID:40258472] | Xiaoyang C, Yijun C, Chenguang Z, Wanyin | J Adv Res | 2026 | 0 |
| High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402] | Du Y, Borné Y, Samuelsson J, Glans I, Hu | Neurology | 2026 | 0 |
| Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Fo [PMID:41410044] | Zhang J, Yu L, Yang W, Cao L, Wang X et | Circulation | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| Covalent Bond Locking in Semiconducting Oligomers Boosts Ultrabright NIR-II Lumi [PMID:41757652] | Li X, Gan H, Zhang C, Gao Y, Zhang J et | Angew Chem Int Ed Engl | 2026 | 0 |
| Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals c [PMID:41781332] | Wang K, Xia W, Gu Y, Zu S, Yang Q et al. | Genome Res | 2026 | 0 |
| HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381] | Hjæresen S, Gramkow ET, Zhang M, Svennin | Prog Neurobiol | 2026 | 0 |
| Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727] | Li D, Zhang Y, Wang R, Jin L, Cui X et a | Neurotherapeutics | 2026 | 0 |
| Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045] | Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O | Age Ageing | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854] | Alcalá Ramírez Del Puerto JM, Ortega-Mad | J Alzheimers Dis | 2026 | 0 |
| Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760] | Bernocchi F, Bonomi CG, Poli M, Di Donna | Neurological sciences : offici | 2026 | 0 |
| Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating s [PMID:41943971] | Aracki-Trenkic A, Živanović M, Milošević | Biomol Biomed | 2026 | 0 |
| Associations between air pollution and markers of neuroinflammation, synaptic dy [PMID:41944915] | Kimura K, Driscoll I, Cook N, Shahzad S, | Neurotoxicity research | 2026 | 0 |