gene 932 words KG: MTCH2
Contents

MTCH2 — Mitochondrial Carrier Homolog 2

🧬 Gene Info
Gene SymbolMTCH2
Full NameMitochondrial Carrier Homolog 2
Chromosome11p15.4
FunctionMTCH2 is a phylogenetically conserved protein that localizes to the outer mitochondrial membrane
Molecular Weight35 kDa
Amino Acids303 aa
PathwaysApoptosis, Stem Cell
UniProt ID[Q9Y6C9](https://www.uniprot.org/uniprot/Q9Y6C9)
Ensembl IDENSG00000135249
OMIM614215
GeneCardsMTCH2
Human Protein AtlasMTCH2
Serves as insertaseFunctions as a mitochondrial outer membrane insertase for proteins [@gonzalez2025]
Regulates mitophagyControls mitophagy initiation and mitochondrial quality control [@yang2025]
Interacts with Bcl-2 familyAssociates with pro-apoptotic and anti-apoptotic proteins
Associated Diseasesneurodegeneration
InteractionsSelH
KG Connections11 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Knowledge Graph (11 edges)

MTCH2 binds tBID
tBID binds MTCH2
Cucurbitacin B binds MTCH2
SelH interacts_with MTCH2
MTCH2 regulates BID
MTCH2 regulates APOPTOSIS
MTCH2 regulates BCL-2
MTCH2 regulates MITOCHONDRIA
MTCH2 regulates Als
MTCH2 regulates Apoptosis

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