gene 932 words KG: MTCH2 2026-03-28
kind:genesection:genesstate:published
Contents

MTCH2 — Mitochondrial Carrier Homolog 2

🧬 Gene Info
Gene SymbolMTCH2
Full NameMitochondrial Carrier Homolog 2
Chromosome11p15.4
FunctionMTCH2 is a phylogenetically conserved protein that localizes to the outer mitochondrial membrane
Molecular Weight35 kDa
Amino Acids303 aa
PathwaysApoptosis, Stem Cell
UniProt ID[Q9Y6C9](https://www.uniprot.org/uniprot/Q9Y6C9)
Ensembl IDENSG00000135249
OMIM614215
GeneCardsMTCH2
Human Protein AtlasMTCH2
Serves as insertaseFunctions as a mitochondrial outer membrane insertase for proteins [@gonzalez2025]
Regulates mitophagyControls mitophagy initiation and mitochondrial quality control [@yang2025]
Interacts with Bcl-2 familyAssociates with pro-apoptotic and anti-apoptotic proteins
Associated Diseasesneurodegeneration
InteractionsSelH
KG Connections11 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: regulates
BID — BH3 Interacting Domain Death Agonist
gene · KG edge: regulates
Mitochondria
entity · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: regulates

Knowledge Graph (11 edges)

MTCH2 binds tBID
MTCH2 regulates BID
MTCH2 regulates APOPTOSIS
MTCH2 regulates BCL-2
MTCH2 regulates MITOCHONDRIA
MTCH2 regulates Als
MTCH2 regulates Apoptosis
MTCH2 regulates Stem Cell
tBID binds MTCH2
Cucurbitacin B binds MTCH2