gene 1,168 words KG: BID 2026-03-27
kind:genesection:genesstate:published
Contents

BID — BH3 Interacting Domain Death Agonist

🧬 Gene Info
Gene SymbolBID
Full NameBH3 Interacting Domain Death Agonist
Chromosome22q11.21
Protein FamilyBCL2 family, BH3-only proteins
Functionis a relatively inactive cytosolic protein.
Molecular Weight22 kDa
Amino Acids195 aa
PathwaysApoptosis, Stem Cell
UniProt IDP55957
NCBI Gene ID637
Ensembl IDENSG00000105619
OMIM603678
GeneCardsBID
Human Protein AtlasBID
N-terminal regionContains caspase-8 cleavage sites (D75, D81)
Associated DiseasesALS, Aging, Alzheimer, Inflammation, Neurodegeneration
InteractionsMTOR, BAD, AKT, BAX, CYP2D6, CYP3A4
KG Connections355 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Purinergic Signaling Polarization Control
Score: 0.55

Related Analyses (9)

Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (19)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Cholinergic System Dysfunction in DLB — Mechanisms and Thera
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: encodes
Alzheimer Indonesia
institution · KG edge: therapeutic_target
ATXN2 Gene
gene · KG edge: encodes
ATR Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

BID associated_with BAD
BID associated_with BAK1
BID associated_with BAX
BID activates MTOR
BID associated_with LAMP2
BID therapeutic_target TLR2
BID associated_with PPP1CB
BID activates BAD
BID therapeutic_target AKT
BID therapeutic_target MTOR