protein 2,462 words KG: ALPHASYNUCLEIN
Contents

Alpha-Synuclein (α-Syn)

🔬 Protein Info
Gene SymbolALPHASYNUCLEIN
AliasesALPHASYNUCLEIN
Chromosome4q21.31
Protein FamilySynuclein family
Subcellular LocalizationPresynaptic terminals, nucleus
Molecular Weight14 kDa (140 aa)
UniProt IDP37840
GeneSNCA
PDB1XQ8, 6A6B, 4R0P
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56

Related Analyses (18)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (30)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Tau Co-Pathology in DLB Clinical Heterogeneity
clinical · proposed · Score: 0.40
DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in