protein 726 words KG: ANK1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Ankyrin-1 Protein

🔬 Protein Info
Gene SymbolANK1
AliasesAnkyrin 1
FunctionAnkyrin 1 is a membrane-associated protein that serves as a critical anchor between the plasma membrane and the underlying cytoskeleton.
Primary ExpressionSubstantia Nigra
Subcellular Localization</th><td>Plasma membrane, Cytoskeleton, Axon initial segment, Nodes of Ranvier</td></tr>
Molecular Weight210 kDa
PathwaysAlpha-Synuclein
Ensembl IDENSG00000162678
GeneCardsANK1
Human Protein AtlasANK1
Associated DiseasesAlzheimer, Parkinson
KG Connections31 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Interferon Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: associated_with
RIT2 — Ras-Like Without CAAX 2 (Rin)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ANK1 associated_with RIT2
ANK1 expressed_in SNCA
ANK1 expressed_in RIT2
ANK1 associated_with ALZHEIMER
ANK1 associated_with PARKINSON
ANK1 expressed_in Neurodegeneration
ANK1 expressed_in Als
ANK1 associated_with Alzheimer
ANK1 associated_with Parkinson
ANK1 expressed_in Neuron