Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Parkinson: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Parkinson is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 2317 entities in the SciDEX knowledge graph.
| Sample Size | 4,018 whole-genome sequencing (WGS) data of blood samples |
| Cohorts | Two independent PD cohorts for validation |
| Analytical Pipeline | Kraken 2 and Bracken software with PlusPF database for microbial annotation |
| Validation | Population-based cross-cohort filtration process with resampling validation |
| Motor dysfunction | Specific bacterial species showed association with motor symptom severity |
| Cognitive impairment | Certain signatures correlated with cognitive decline in PD patients |
| Associated Genes | STIP1, LGALS3, HSPA8, MCOLN1, SQSTM1, SOD1, BCL2, CTSB |
| KG Connections | 3769 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
HCN1["HCN1"] -->|"regulates"| Parkinson["Parkinson"]
HCN4["HCN4"] -->|"regulates"| Parkinson["Parkinson"]
HCN2["HCN2"] -->|"regulates"| Parkinson["Parkinson"]
CAT["CAT"] -->|"interacts"| Parkinson["Parkinson"]
style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | associated_with | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Multiple Sclerosis | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Depression | associated_with | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Mitophagy | associated_with | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Proteasome | therapeutic_target | pathway | 1.00 |
| Ferroptosis | associated_with | pathway | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Inflammation | contributes_to | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Alzheimer | causes | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Alzheimer | implicated_in | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NRF2 | activates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| NRF2 | therapeutic_target | gene | 1.00 |
| PINK1 | regulates | gene | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| LRRK2 | associated_with | gene | 1.00 |
| OVERVIEW | associated_with | gene | 1.00 |
| LRRK2 | causes | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | contributes_to | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| 6-OHDA | activates | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| UBIQUITIN | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| ALPHA-SYNUCLEIN | associated_with | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||