| Gene Symbol | LRP8 |
| Aliases | LDLRR, LR8, APOER2 |
| Chromosome | 1p31.3 |
| Protein Type | Receptor |
| Function | Neuronal migration: Reelin-LRP8/Dab1 signaling regulates cortical lamination |
| Primary Expression | Brain (neurons), testis, platelets |
| Molecular Weight | ~110 kDa (full-length), 85 kDa (truncated) |
| Amino Acids | 870 aa |
| Exons | 31 |
| Pathways | Cardiovascular Homeostasis |
| UniProt ID | Q9UBJ2 |
| Ensembl ID | ENSG00000157193 |
| GeneCards | LRP8 |
| Human Protein Atlas | LRP8 |
| Protein Name | Apolipoprotein E Receptor 2 (ApoER2) |
| Associated Diseases | ALS, Aging, Alzheimer, Atherosclerosis, Cancer |
| Interactions | TRKB, AKT, APOA1, APOE, CYP46A1, ABCA1 |
| KG Connections | 192 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |