protein 1,153 words KG: AUXILINPROTEIN 2026-03-30
kind:proteinsection:proteinstopic:parkinsonstopic:alzheimerstopic:als
Contents

Auxilin Protein

🔬 Protein Info
Gene SymbolAUXILIN
AliasesAUXILINPROTEIN
Chromosome1p31.3
FunctionAuxilin is specifically expressed in neurons and neuroendocrine cells where CME is heavily used.
Primary ExpressionNeuron-specific
Molecular Weight97 kDa
Amino Acids826 aa
Exons15
GeneCardsAUXILIN
Human Protein AtlasAUXILIN
InteractorRelationship
Hsp70/HSPA8J domain binding
Clathrin (CLTC)PTB + C-terminal binding
AP-2 complexPTB domain interaction
DNAJC6 (cyclin-dependent kinase)Post-translational modification
Associated DiseasesParkinson's disease, Alzheimer's disease, ALS
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 6 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 6 hypotheses
Endosomal Sorting Defects in Neurodegeneration
mechanism · Pages share 6 hypotheses