protein 604 words KG: CALCINEURINPROTEIN
Contents

Calcineurin Protein

🔬 Protein Info
Gene SymbolPPP3CA
AliasesProtein Phosphatase 3 Catalytic Subunit Alpha
Protein TypePhosphatase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight58.7 kDa
Amino Acids521 aa
PathwaysAutophagy, Complement, Endocytosis, Exocytosis, Mitophagy
Ensembl IDENSG00000143510
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
Associated DiseasesALS, Bipolar, Heart Failure, Schizophrenia
InteractionsALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections302 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (12)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses
Retinal Degeneration Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses
Convergent Pathways in Neurodegeneration
mechanism · Pages share 7 hypotheses
Dystrophic Neurites in Neurodegeneration
mechanism · Pages share 7 hypotheses
HMGB1 Signaling in Neurodegeneration
mechanism · Pages share 7 hypotheses

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