protein 604 words KG: CALCINEURINPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Calcineurin Protein

🔬 Protein Info
Gene SymbolPPP3CA
AliasesProtein Phosphatase 3 Catalytic Subunit Alpha
Protein TypePhosphatase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight58.7 kDa
Amino Acids521 aa
PathwaysAutophagy, Complement, Endocytosis, Exocytosis, Mitophagy
Ensembl IDENSG00000143510
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
Associated DiseasesALS, Bipolar, Heart Failure, Schizophrenia
InteractionsATG12, STUB1, PPARGC1A, TARDBP, TREH, BECN1
KG Connections308 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (12)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 7 hypotheses
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 7 hypotheses
Therapeutic Targets in Neurodegeneration
mechanism · Pages share 7 hypotheses
Sex Differences in Neurodegeneration
mechanism · Pages share 7 hypotheses
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 7 hypotheses