| Gene Symbol | CAPZB |
| Full Name | Capping Actin Protein of the Z-disc Beta |
| Chromosome | 1p36.22 |
| Function | This binding prevents the addition or loss of actin subunits at this end, functioning through several mechanisms |
| Primary Expression | the brain with specific patterns: |
| Subcellular Localization | , or impaired post-translational modification could compromise actin dynamics during neurodegeneration |
| Molecular Weight | 31 kDa |
| UniProt ID | P47756 |
| NCBI Gene ID | 832 |
| Ensembl ID | ENSG00000015590 |
| OMIM | 601568 |
| GeneCards | CAPZB |
| Human Protein Atlas | CAPZB |
| Modulating actin pool distribution | By controlling where free barbed ends exist, CAPZB influences the spatial organization of actin polymerization within neuronal compartments |
| Regulating synapse structure | The protein affects dendritic spine density and morphology through its influence on the actin cytoskeleton |
| Associated Diseases | ALS, Alzheimer |
| Known Drugs/Compounds | aducanumab |
| Interactions | NDUFS7, NDUFA4, Proteins, NEURODEGENERATIVE DISEASES, PLCB1, CD81 |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsHPASTRING |