PLCB1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLCB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PLCB1 encodes phospholipase C beta 1, a key enzyme in phosphoinositide signaling that regulates calcium dynamics, synaptic plasticity, and neuronal function

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graph TD
    PLCB1["<b>PLCB1</b>"]
    Alzheimer["Alzheimer"]
    PLCB1 -->|"associated with"| Alzheimer
    Als["Als"]
    PLCB1 -->|"associated with"| Als
    ALS["ALS"]
    PLCB1 -->|"associated with"| ALS
    NDUFS7["NDUFS7"]
    PLCB1 -->|"regulates"| NDUFS7
    CAPZB["CAPZB"]
    PLCB1 -->|"regulates"| CAPZB
    NDUFA4["NDUFA4"]
    PLCB1 -->|"regulates"| NDUFA4
    CD81["CD81"]
    PLCB1 -->|"regulates"| CD81
    Amyloid["Amyloid"]
    PLCB1 -->|"associated with"| Amyloid
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"regulates"| PLCB1
    CD81["CD81"]
    CD81 -->|"regulates"| PLCB1
    GDI2["GDI2"]
    GDI2 -->|"regulates"| PLCB1
    MAG["MAG"]
    MAG -->|"regulates"| PLCB1
    HK1["HK1"]
    HK1 -->|"regulates"| PLCB1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| PLCB1
    CAPZB["CAPZB"]
    CAPZB -->|"regulates"| PLCB1
    NDUFS7["NDUFS7"]
    NDUFS7 -->|"regulates"| PLCB1
    NDUFA4["NDUFA4"]
    NDUFA4 -->|"regulates"| PLCB1
    AND["AND"]
    AND -->|"regulates"| PLCB1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| PLCB1
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| PLCB1
    CD81["CD81"]
    PLCB1 -->|"interacts with"| CD81
    GDI2["GDI2"]
    PLCB1 -->|"interacts with"| GDI2
    CAPZB["CAPZB"]
    PLCB1 -->|"interacts with"| CAPZB
    NDUFS7["NDUFS7"]
    PLCB1 -->|"interacts with"| NDUFS7
    NDUFA4["NDUFA4"]
    PLCB1 -->|"interacts with"| NDUFA4
    Proteins["Proteins"]
    PLCB1 -->|"interacts with"| Proteins
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"interacts with"| PLCB1
    neurodegeneration["neurodegeneration"]
    PLCB1 -->|"implicated in"| neurodegeneration