gene

CD81

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD81: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

Summary

CD81 is a tetraspanin membrane protein involved in exosome biology, neuroinflammation, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	CD81
Full Name	Cluster of Differentiation 81
Chromosome	11p15.5
Primary Expression	immune cells, epithelial cells, and most notably for neurodegeneration research, in neurons and glial cells of the central nervous system
Molecular Weight	26 kDa
Amino Acids	236 aa
Exons	9
Pathways	oxidative stress response, unfolded protein response
UniProt ID	[P60033](https://www.uniprot.org/uniprot/P60033)
Ensembl ID	ENSG00000110601
GeneCards	CD81
Human Protein Atlas	CD81
Associated Diseases	ALS, Alzheimer
Known Drugs/Compounds	aducanumab
Interactions	CD4, CD63, GDI2, CAPZB, NDUFS7, NDUFA4
KG Connections	91 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD81["<b>CD81</b>"]
    Carcinoma{"Carcinoma"}
    CD81 -->|"therapeutic target"| Carcinoma
    Cirrhosis{"Cirrhosis"}
    CD81 -->|"therapeutic target"| Cirrhosis
    Hepatitis{"Hepatitis"}
    CD81 -->|"therapeutic target"| Hepatitis
    Inflammation{"Inflammation"}
    CD81 -->|"therapeutic target"| Inflammation
    CLDN1["CLDN1"]
    CD81 -->|"therapeutic target"| CLDN1
    LDLR["LDLR"]
    CD81 -->|"associated with"| LDLR
    INFLAMMATION["INFLAMMATION"]
    CD81 -->|"therapeutic target"| INFLAMMATION
    EGFR["EGFR"]
    CD81 -->|"associated with"| EGFR
    OCLN["OCLN"]
    CD81 -->|"therapeutic target"| OCLN
    POLE["POLE"]
    CD81 -->|"therapeutic target"| POLE
    neurodegeneration["neurodegeneration"]
    CD81 -->|"implicated in"| neurodegeneration
    style CD81 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (62)

Target	Relation	Type	Str
Carcinoma	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
CLDN1	therapeutic_target	gene	0.60
LDLR	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
OCLN	therapeutic_target	gene	0.60
POLE	therapeutic_target	gene	0.60
CD4	inhibits	gene	0.60
CD63	interacts_with	gene	0.60
GDI2	regulates	gene	0.60
MAG	regulates	gene	0.60
HK1	regulates	gene	0.60
PLCB1	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
CAPZB	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
CD9	interacts_with	gene	0.60
GLS	associated_with	gene	0.60
L1CAM	associated_with	gene	0.60
CD9	associated_with	gene	0.60
CD9	expressed_in	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
EXOSOMES	inhibits	gene	0.60
Microrna	inhibits	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Actin	interacts_with	protein	0.60
Interleukin	interacts_with	protein	0.60
Aβ	regulates	protein	0.60
Fus	interacts_with	protein	0.60
App	interacts_with	protein	0.60
MITOCHONDRIA	regulates	gene	0.60
Raf	regulates	protein	0.60
App	associated_with	protein	0.60
ASTROCYTES	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Neuron	associated_with	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
lipid metabolism	participates_in	pathway	0.60

Incoming (29)

Source	Relation	Type	Str
FOXP3	inhibits	gene	0.60
CD63	expressed_in	gene	0.60
CD9	interacts_with	gene	0.60
HK1	regulates	gene	0.60
CAPZB	regulates	gene	0.60
GDI2	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
MAG	regulates	gene	0.60
PLCB1	regulates	gene	0.60
CD63	associated_with	gene	0.60
CD9	associated_with	gene	0.60
aducanumab	targets	drug	0.60
MIRNAS	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
CD63	activates	gene	0.55
CD63	biomarker_for	gene	0.55
CD63	interacts_with	gene	0.50
PLCB1	interacts_with	gene	0.50
CAPZB	co_expressed_with	protein	0.50
MITOCHONDRIA	interacts_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD81

Understanding Entity Pages

Summary

Wiki Pages (21)

CD81

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Exosome and Extracellular Vesicle Brain Delivery

Cell-to-cell transmission of alpha-synuclein

Extracellular Vesicles in Neurodegeneration

Exosome Biogenesis in Neurodegeneration

Extracellular Vesicle-Mediated Synuclein Propagation Hypothesis in Parkinson's Disease

Exosome-Mediated Pathological Protein Propagation

Engineered Exosomes for Intranasal CNS Delivery

Alpha-Synuclein Exosomal Secretion

Exosome-Based Therapeutics for Neurodegenerative Diseases

CBS/PSP Tau Strain Biomarker Validation for Clinical Trial Stratification

Astrocyte-Derived Exosomal mRNA Reference Genes for Alzheimer's Disease

CD9

Exosomes

CR2 (Complement Receptor Type 2)

Exosome-Secreting Neurons

Exosome Therapy for Neurodegenerative Diseases

CD63

Pathway Diagram

Outgoing (62)

Incoming (29)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)