| Gene Symbol | GEMIN6 |
| Full Name | Gem-Associated Protein 6 |
| Aliases | GEMIN6PROTEIN |
| Chromosome | 2p16.3 |
| Function | is a component of the SMN (Survival of Motor Neurons) complex, which is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs) crucial for pre-mRNA splicing. |
| Primary Expression | motor neurons, and mutations in SMN1 (the primary SMA-causing gene) lead to spinal muscular atrophy (SMA) |
| Subcellular Localization | Cajal bodies (coiled bodies) within the nucleus, where it orchestrates the recruitment of the heptameric Sm protein comp |
| Amino Acids | 244 aa |
| UniProt ID | [Q9Y5B2](https://www.uniprot.org/uniprotkb/Q9Y5B2) |
| Ensembl ID | ENSG00000179750 |
| OMIM | 609651 |
| GeneCards | GEMIN6 |
| Human Protein Atlas | GEMIN6 |
| Subcomplex formation | The Gemin-6/Gemin-7 heterodimer is exceptionally stable, with a binding affinity in the nanomolar range. This stability is achieved through complementary hydrophobic surfaces and ionic interactions. |
| Extended interface | The Gemin-6/7 dimer provides a platform for Gemin-8 binding, creating the trimeric subcomplex. The Gemin-8 binding interface is distinct from the Gemin-7 interface, allowing sequential assembly. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |