disease

Ataxia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ataxia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

827Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Ataxia is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 397 entities in the SciDEX knowledge graph.

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Disease Info

Purkinje Cells	primary synaptic targets of granule cell parallel fibers
Spinocerebellar Ataxias (SCAs)	major group of neurodegenerative ataxias affecting granule cells
Friedreich's Ataxia	cardiomyopathy-associated ataxia with marked granule cell pathology
Associated Genes	STIP1, LGALS3, HSPA8, MCOLN1, SQSTM1, SOD1, BCL2, CTSB
KG Connections	746 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cerebellar Granule Cells in Ataxia

cell · 680 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Ataxia["Ataxia"] -->|"associated"| Mtor["Mtor"]
    Ataxia["Ataxia"] -->|"associated"| Autophagy["Autophagy"]
    Ataxia["Ataxia"] -->|"therapeutic target"| Immune_Response["Immune Response"]
    Ataxia["Ataxia"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    Ataxia["Ataxia"] -->|"therapeutic target"| Mitochondrial_Function["Mitochondrial Function"]
    Ataxia["Ataxia"] -->|"associated"| Oxidative_Stress_1["Oxidative Stress"]
    STIP1["STIP1"] -->|"associated"| Ataxia["Ataxia"]
    LGALS3["LGALS3"] -->|"associated"| Ataxia["Ataxia"]
    HSPA8["HSPA8"] -->|"associated"| Ataxia["Ataxia"]
    MCOLN1["MCOLN1"] -->|"associated"| Ataxia["Ataxia"]
    style Ataxia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (250)

Target	Relation	Type	Str
Als	associated_with	disease	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Parkinson	associated_with	disease	0.85
Neurodegeneration	implicated_in	disease	0.85
Neurodegeneration	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Oxidative Stress	activates	pathway	0.70
Mitochondrial Function	inhibits	pathway	0.70
Multiple Sclerosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	implicated_in	disease	0.65
Als	activates	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Autophagy	implicated_in	pathway	0.60
Proteasome	implicated_in	pathway	0.60
Senescence	inhibits	pathway	0.60
Dna Repair	activates	pathway	0.60
Differentiation	activates	pathway	0.60
Cell Division	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Cell Cycle	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Immune Response	treats	pathway	0.60
Mitochondrial Function	implicated_in	pathway	0.60
Oxidative Stress	implicated_in	pathway	0.60
Chaperone	implicated_in	pathway	0.60
Huntington	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Inflammation	associated_with	disease	0.55
Cardiac	associated_with	disease	0.55
Chaperone	associated_with	pathway	0.55

Incoming (577)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
GENES	activates	gene	0.95
PARKINSON	associated_with	gene	0.95
HUNTINGTON	associated_with	gene	0.95
DEMENTIA	associated_with	gene	0.95
NEURODEGENERATION	implicated_in	gene	0.95
DNA	associated_with	gene	0.85
ALS	associated_with	gene	0.85
CANCER	activates	gene	0.85
ATM	activates	gene	0.85
NEURODEGENERATION	associated_with	gene	0.85
Huntington	associated_with	disease	0.85
DNA	activates	gene	0.85
PARKINSON	activates	gene	0.85
Reducing Stress Granule Formation	contributes_to	process	0.85
Stress Granule Formation	protects_against	process	0.85
SCA3	associated_with	gene	0.75
DNA	therapeutic_target	gene	0.75
NRF2	therapeutic_target	gene	0.75
C9ORF72	associated_with	gene	0.75
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.75
NEUROINFLAMMATION	therapeutic_target	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
ENDOSOMES	associated_with	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
POLG	associated_with	gene	0.75
P53	activates	gene	0.75
MITOPHAGY	inhibits	gene	0.75
NEURODEGENERATIVE DISEASES	associated_with	gene	0.75
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.75
HUNTINGTON'S DISEASE	associated_with	gene	0.75
NEURODEGENERATION	regulates	gene	0.75
ALZHEIMER	associated_with	gene	0.75
DRP1	associated_with	gene	0.75
AMYLOID	implicated_in	gene	0.75
APP	implicated_in	gene	0.75
HUNTINGTON	activates	gene	0.75
ALZHEIMER	activates	gene	0.75
GAIN	implicated_in	gene	0.75
ATXN1	causes	gene	0.75
BDNF	protects_against	gene	0.75
STIP1	associated_with	gene	0.65
LGALS3	associated_with	gene	0.65
HSPA8	associated_with	gene	0.65
MCOLN1	associated_with	gene	0.65
SQSTM1	associated_with	gene	0.65
SOD1	associated_with	gene	0.65
BCL2	associated_with	gene	0.65
CTSB	associated_with	gene	0.65
TPP1	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Ataxia

Understanding Entity Pages

Summary

Wiki Pages (21)

Cerebellar Granule Cells in Ataxia

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Therapeutics

Multiple System Atrophy

TREM2 Mechanism Hub

HNRNPA2B1 Protein

Growth Factor Therapies

Synucleinopathy Mechanism

Oligodendrocytes

Huntington's Disease