gene

ATG12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

460Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ATG12 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 335 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG12
Full Name	Autophagy Related 12
Chromosome	5q21.2
Protein Family	ATG12 family
Function	is a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins.
Subcellular Localization	Cytoplasm, autophagosome membrane
Molecular Weight	~15 kDa
Pathways	Autophagy, Cell Cycle, Mitophagy
UniProt ID	O95166
NCBI Gene ID	9459
Ensembl ID	ENSG00000181458
GeneCards	ATG12
Human Protein Atlas	ATG12
Associated Diseases	Als, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AGING, AKT, ALS, ALZHEIMER, AMPK
KG Connections	460 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG12 — AlphaFold O95166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG12["ATG12"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG12["ATG12"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ATG12["ATG12"] -->|"activates"| Ataxia["Ataxia"]
    ATG12["ATG12"] -->|"activates"| Als["Als"]
    ATG12["ATG12"] -->|"activates"| Parkinson["Parkinson"]
    ATG12["ATG12"] -->|"activates"| Huntington["Huntington"]
    SQSTM1["SQSTM1"] -->|"participates in"| ATG12["ATG12"]
    AKT["AKT"] -->|"associated"| ATG12["ATG12"]
    AMPK["AMPK"] -->|"associated"| ATG12["ATG12"]
    APP["APP"] -->|"associated"| ATG12["ATG12"]
    style ATG12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (283)

Target	Relation	Type	Str
Als	activates	disease	0.85
Autophagy	interacts_with	pathway	0.80
Autophagy	activates	pathway	0.80
Cancer	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
AUTOPHAGY	activates	gene	0.70
Mtor	activates	pathway	0.70
ULK1	interacts_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
MTOR	activates	gene	0.70
Alzheimer	interacts_with	disease	0.65
Infection	interacts_with	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Infection	associated_with	disease	0.65
Autoimmune	inhibits	disease	0.65
Bacterial Infection	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	associated_with	disease	0.65
NEURON	associated_with	gene	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
TAU	associated_with	gene	0.65
Tumor	inhibits	disease	0.65
Lung Cancer	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	interacts_with	disease	0.65
Ataxia	implicated_in	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
TAUOPATHY	associated_with	gene	0.65
Als	expressed_in	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ataxia	activates	disease	0.65
Parkinson	activates	disease	0.65
Tumor	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Glioma	regulates	disease	0.65
MITOCHONDRIA	associated_with	gene	0.65
TFEB	associated_with	gene	0.65
ATG5	associated_with	gene	0.65
SIRT1	associated_with	gene	0.65
Huntington	activates	disease	0.65
Aging	interacts_with	disease	0.65
ALS	activates	disease	0.65
Spinocerebellar Ataxia	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Neuroblastoma	activates	disease	0.65

Incoming (177)

Source	Relation	Type	Str
L1CAM	interacts_with	protein	0.90
SQSTM1	participates_in	gene	0.80
ATG5	activates	gene	0.80
P62	activates	gene	0.80
ATG	interacts_with	gene	0.80
LC3	interacts_with	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
AUTOPHAGY	activates	gene	0.80
GENES	activates	gene	0.70
ATG5	interacts_with	gene	0.70
UBIQUITIN	interacts_with	gene	0.70
CANCER	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
LC3	activates	gene	0.70
Mir-221-3P	inhibits	gene	0.70
AKT	associated_with	gene	0.65
APP	associated_with	gene	0.65
AMPK	associated_with	gene	0.65
PHGDH	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PROTEIN MISFOLDING	associated_with	gene	0.60
RNA	associated_with	gene	0.60
LNCRNA	activates	gene	0.60
AND	inhibits	gene	0.60
MAP1LC3	interacts_with	gene	0.60
LC3B	associated_with	gene	0.60
ALS	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
AND	activates	gene	0.60
MIRNAS	inhibits	gene	0.60
ATG	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY-RELATED GENES	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60
ACTB	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
GFP	interacts_with	gene	0.60
ATG9	interacts_with	gene	0.60
RNA	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ZDHHC7	interacts_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
GFP	therapeutic_target	gene	0.60
MITOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What validated biomarkers can determine optimal TFEB activity windows during dis

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate proposed temporal TFEB modulation but identified no validated biomark

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning ATG12 in their description or question text

No additional research found