gene

STUB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STUB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

STUB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 138 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STUB1
Full Name	STIP1 Homology And U-Box Containing Protein 1
Aliases	CHIP
Chromosome	16p13.3
Protein Family	U-box E3 ubiquitin ligase family
Function	encodes a ubiquitin ligase and cochaperone that plays critical roles in protein quality control
Molecular Weight	34.6 kDa
Amino Acids	305 aa
Pathways	Chaperone, Proteasome, Ubiquitin-Proteasome
UniProt ID	Q9UNE7
NCBI Gene ID	10273
Ensembl ID	ENSG00000120539
OMIM	607207
GeneCards	STUB1
Human Protein Atlas	STUB1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Ms, Neuroblastoma
Known Drugs/Compounds	rapamycin
Interactions	ATG10, CALCINEURIN, ATG12, BAG3, HSPB8, SNAP29
KG Connections	242 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STUB1 — AlphaFold Q9UNE7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STUB1["STUB1"]
    STUB1 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    STUB1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    STUB1 -->|"activates"| Carcinoma["Carcinoma"]
    STUB1 -->|"activates"| Ms["Ms"]
    STUB1 -->|"activates"| ATG10["ATG10"]
    STUB1 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    STUB1 -->|"activates"| ATG12["ATG12"]
    STUB1 -->|"interacts"| BAG3["BAG3"]
    STUB1 -->|"interacts"| HSPB8["HSPB8"]
    STUB1 -->|"activates"| Autophagy["Autophagy"]
    CALCINEURIN -->|"activates"| STUB1
    ATG12 -->|"activates"| STUB1
    GENES["GENES"] -->|"activates"| STUB1
    DNA["DNA"] -->|"activates"| STUB1
    SNAP29["SNAP29"] -->|"activates"| STUB1
    STX17["STX17"] -->|"activates"| STUB1
    DRAM1["DRAM1"] -->|"regulates"| STUB1
    HSPB8 -->|"interacts"| STUB1
    BAG3 -->|"interacts"| STUB1
    VAMP8["VAMP8"] -->|"regulates"| STUB1

Outgoing (123)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
LAMP1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
BAG3	interacts_with	gene	0.60
HSPB8	interacts_with	gene	0.60
VAMP8	regulates	gene	0.60
SNAP29	activates	gene	0.60
FMR1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
TAK1	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
MTOR	inhibits	gene	0.60
P62	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TFEB	inhibits	gene	0.60

Incoming (119)

Source	Relation	Type	Str
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
SNAP29	activates	gene	0.60
STX17	activates	gene	0.60
DRAM1	regulates	gene	0.60
HSPB8	interacts_with	gene	0.60
BAG3	interacts_with	gene	0.60
VAMP8	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
WFS1	associated_with	gene	0.60
HARS	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
SETX	associated_with	gene	0.60
LARS2	associated_with	gene	0.60
POLG	associated_with	gene	0.60
SIL1	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
TRAF6	interacts_with	gene	0.60
TREH	associated_with	gene	0.60
ATG10	activates	gene	0.60
BECN1	associated_with	gene	0.60
TFEB	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STUB1

Understanding Entity Pages

Summary

Wiki Pages (21)

STUB1 — CHIP

proteasome-ubiquitin-system-dysfunction-parkinsons

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

ubiquitin-proteasome-dysfunction-neurodegeneration

Tau Proteostasis and Clearance Across 4R-Tauopathies

Chaperone-Mediated Proteostasis Disease Comparison

ATXN9 - Ataxin-9

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

Proteostasis Network in Neurodegeneration

Section 204: Advanced Proteostasis and Protein Quality Control in CBS/PSP

Ubiquitin-Proteasome System in Neurodegeneration

Ubiquitin-Proteasome System Dysfunction in Alzheimer's Disease

E3 Ubiquitin Ligase System in Neurodegeneration

PARK2 Protein

Ubiquitin-Proteasome System Dysfunction in Corticobasal Syndrome

DNAJC14 (DnaJ Heat Shock Protein Family Member C14) Protein

Advanced Proteolysis and Ubiquitin System Targeting in CBS/PSP

Ubiquitin Signatures on Aggregating Proteins