disease

Neuroblastoma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neuroblastoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	ATG, BAG3, BCL2, BECN1, CTSB, GAPDH, GLA, HSPA8
KG Connections	272 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Neuroblastoma["<b>Neuroblastoma</b>"]
    Neurodegeneration{"Neurodegeneration"}
    Neuroblastoma -->|"activates"| Neurodegeneration
    Cancer{"Cancer"}
    Neuroblastoma -->|"therapeutic_target"| Cancer
    Als{"Als"}
    Neuroblastoma -->|"activates"| Als
    Mtor["Mtor"]
    Neuroblastoma -->|"therapeutic_target"| Mtor
    Pi3K_Akt["Pi3K/Akt"]
    Neuroblastoma -->|"therapeutic_target"| Pi3K_Akt
    Oxidative_Stress["Oxidative Stress"]
    Neuroblastoma -->|"activates"| Oxidative_Stress
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATION -->|"activates"| Neuroblastoma
    AKT(["AKT"])
    AKT -->|"therapeutic_target"| Neuroblastoma
    PI3K(["PI3K"])
    PI3K -->|"therapeutic_target"| Neuroblastoma
    MTOR(["MTOR"])
    MTOR -->|"therapeutic_target"| Neuroblastoma
    style Neuroblastoma fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (125)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.85
Cancer	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Mtor	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	activates	disease	0.65
Differentiation	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Nf-Kb	activates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Mtor	activates	pathway	0.60
Receptor Tyrosine Kinase	inhibits	pathway	0.60
Immune Checkpoint	inhibits	pathway	0.60
Metastasis	therapeutic_target	pathway	0.60
Stem Cell	activates	pathway	0.60
Dna Methylation	protects_against	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
Differentiation	biomarker_for	pathway	0.60
Epigenetic	protects_against	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
Senescence	activates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Autophagy	associated_with	pathway	0.55
Chaperone	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Parkinson	implicated_in	disease	0.55
Neurodegeneration	implicated_in	disease	0.55
Aging	therapeutic_target	disease	0.55
Lymphoma	therapeutic_target	disease	0.55
Alzheimer	associated_with	disease	0.55
Huntington	associated_with	disease	0.55
Ataxia	associated_with	disease	0.55
Als	associated_with	disease	0.55
Amyotrophic Lateral Sclerosis	associated_with	disease	0.55
Tumor	activates	disease	0.55
Neuroinflammation	activates	disease	0.55
Inflammation	activates	disease	0.55
Neurodegeneration	inhibits	disease	0.55
Breast Cancer	activates	disease	0.55
Als	inhibits	disease	0.55

Incoming (230)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.95
AKT	therapeutic_target	gene	0.75
PI3K	therapeutic_target	gene	0.75
MTOR	therapeutic_target	gene	0.75
CANCER	therapeutic_target	gene	0.75
PARKINSON	associated_with	gene	0.75
GENES	activates	gene	0.75
ROS	activates	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
AUTOPHAGY	activates	gene	0.75
MITOPHAGY	activates	gene	0.75
LC3	activates	gene	0.75
CANCER	activates	gene	0.75
ALZHEIMER	activates	gene	0.75
ALZHEIMER'S DISEASE	activates	gene	0.75
ATG	associated_with	gene	0.65
ATG10	activates	gene	0.65
ATG12	activates	gene	0.65
BAG3	associated_with	gene	0.65
BCL2	associated_with	gene	0.65
BECN1	associated_with	gene	0.65
CALCINEURIN	activates	gene	0.65
CTSB	associated_with	gene	0.65
GAPDH	associated_with	gene	0.65
GLA	associated_with	gene	0.65
HSPA8	associated_with	gene	0.65
HSPB8	associated_with	gene	0.65
LAMP1	associated_with	gene	0.65
LAMP2A	associated_with	gene	0.65
LGALS3	associated_with	gene	0.65
MAP1LC3B	associated_with	gene	0.65
MCOLN1	associated_with	gene	0.65
MTOR	associated_with	gene	0.65
P62	associated_with	gene	0.65
PPARGC1A	associated_with	gene	0.65
PPP3	associated_with	gene	0.65
PPP3CB	associated_with	gene	0.65
SOD1	associated_with	gene	0.65
SQSTM1	associated_with	gene	0.65
STIP1	associated_with	gene	0.65
STUB1	associated_with	gene	0.65
TARDBP	associated_with	gene	0.65
TFEB	associated_with	gene	0.65
TPP1	associated_with	gene	0.65
TREH	associated_with	gene	0.65
C9ORF72	interacts_with	gene	0.65
RAB7L1	interacts_with	gene	0.65
FAM38A	activates	gene	0.65
FAM38B	activates	gene	0.65
PIEZO1	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Neuroblastoma

Understanding Entity Pages

Wiki Pages (20)

NPM1 Gene

metal-ion-synuclein-mitochondria-axis-parkinsons

RPL30 — Ribosomal Protein L30 in Neurodegeneration

Curcumin for Neurodegeneration

proteasome-ubiquitin-system-dysfunction-parkinsons

creatine-supplementation-neurodegeneration

CNTFR Gene

Biomolecular Condensates in Neurodegeneration

Cytochrome c Protein

PNMT Protein

Ferroptotic Neurons

RAB9A

BAG5 Gene

TBX2 — T-Box Transcription Factor 2

RNASEK — Ribonuclease Kappa

TEAD1 — TEA Domain Transcription Factor 1

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

NSUN2 Gene