concept

NEUROBLASTOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROBLASTOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

425Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NEUROBLASTOMA is a concept in neurodegeneration research. Key relationships include: interacts with, activates, co discussed. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA. Connected to 21 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NEUROBLASTOMA
Key Genes/Proteins	ACHE, AD, ADAM10, ADAM17, ALK, ALS
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	APOPTOSIS

Pathway Diagram

graph TD
    NEUROBLASTOMA["NEUROBLASTOMA"]
    NEUROBLASTOMA -->|"activates"| P62["P62"]
    NEUROBLASTOMA -->|"activates"| SOD1["SOD1"]
    NEUROBLASTOMA -->|"activates"| SQSTM1["SQSTM1"]
    NEUROBLASTOMA -->|"activates"| TARDBP["TARDBP"]
    NEUROBLASTOMA -->|"activates"| TFEB["TFEB"]
    NEUROBLASTOMA -->|"expressed in"| SENESCENCE["SENESCENCE"]
    NEUROBLASTOMA -->|"promotes"| NEURON["NEURON"]
    ATG10["ATG10"] -->|"activates"| NEUROBLASTOMA
    ATG12["ATG12"] -->|"activates"| NEUROBLASTOMA
    CALCINEURIN["CALCINEURIN"] -->|"activates"| NEUROBLASTOMA
    C9ORF72["C9ORF72"] -->|"interacts"| NEUROBLASTOMA
    RAB7L1["RAB7L1"] -->|"interacts"| NEUROBLASTOMA
    FAM38A["FAM38A"] -->|"activates"| NEUROBLASTOMA
    FAM38B["FAM38B"] -->|"activates"| NEUROBLASTOMA
    PIEZO1["PIEZO1"] -->|"activates"| NEUROBLASTOMA
    PIEZO2["PIEZO2"] -->|"activates"| NEUROBLASTOMA
    ALS["ALS"] -->|"interacts"| NEUROBLASTOMA
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| NEUROBLASTOMA
    ATAXIA["ATAXIA"] -->|"activates"| NEUROBLASTOMA

Outgoing (146)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.85
Cancer	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Mtor	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Autophagy	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Cancer	activates	disease	0.65
DOPAMINE	inhibits	phenotype	0.65
Alzheimer	activates	disease	0.65
AMYLOID	treats	protein	0.65
PARKIN	produces	gene	0.65
PARKIN	modifies	gene	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
NEURONS	processes	cell_type	0.65
PINK1	causes	gene	0.65
CHRNA7	protects_against	gene	0.65
STING	biomarker_for	gene	0.65
NEURON	promotes	cell_type	0.60
NEURON	expressed_in	cell_type	0.60
PARP1	activates	gene	0.60
NEURON	inhibits	cell_type	0.60
NEURONS	inhibits	cell_type	0.60
Stem Cell	associated_with	pathway	0.60
PINK1	associated_with	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
Stem Cell	activates	pathway	0.60
Mtor	activates	pathway	0.60
STING	inhibits	gene	0.60
NEURONS	activates	cell_type	0.60
STING	expresses	gene	0.60
NEURON	markers	cell_type	0.60
TAU	interacts_with	gene	0.60
NEURONS	expresses	cell_type	0.60
Metastasis	therapeutic_target	pathway	0.60
PD	co_discussed	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Senescence	activates	pathway	0.60
TREM2	enhances	gene	0.60
TAU	co_discussed	gene	0.60
OXIDATIVE STRESS	inhibits	pathway	0.60
NEURON	co_discussed	cell_type	0.60
Differentiation	biomarker_for	pathway	0.60
Epigenetic	protects_against	pathway	0.60
SQSTM1	activates	gene	0.60
TARDBP	activates	gene	0.60

Incoming (279)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.95
GENES	activates	gene	0.75
CANCER	therapeutic_target	gene	0.75
ROS	activates	gene	0.75
MTOR	therapeutic_target	gene	0.75
PI3K	therapeutic_target	gene	0.75
MITOPHAGY	activates	gene	0.75
LC3	activates	gene	0.75
PARKINSON	associated_with	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
AUTOPHAGY	activates	gene	0.75
AKT	therapeutic_target	gene	0.75
ALZHEIMER	activates	gene	0.75
ALZHEIMER'S DISEASE	activates	gene	0.75
CANCER	activates	gene	0.75
OGT	activates	gene	0.65
MITOCHONDRIA	activates	gene	0.65
ATP	activates	gene	0.65
NEURODEGENERATION	inhibits	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65
ALPHA-SYNUCLEIN	inhibits	gene	0.65
NEURODEGENERATION	protects_against	gene	0.65
RAS	inhibits	gene	0.65
ERK	inhibits	gene	0.65
PTEN	activates	gene	0.65
PINK1	activates	gene	0.65
PIEZO1	activates	gene	0.65
PIEZO2	activates	gene	0.65
TREHALOSE	activates	gene	0.65
NEURODEGENERATIVE DISEASES	associated_with	gene	0.65
ALS	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
DNA	associated_with	gene	0.65
UBIQUITIN	associated_with	gene	0.65
FAM38B	activates	gene	0.65
AMYLOID	activates	gene	0.65
DNA	activates	gene	0.65
OPTN	activates	gene	0.65
MYC	interacts_with	gene	0.65
MYC	activates	gene	0.65
MYC	targets	gene	0.65
FAM38A	activates	gene	0.65
GABRP	activates	gene	0.65
NEURODEGENERATION	implicated_in	gene	0.65
P38	activates	gene	0.65
PARKIN	activates	gene	0.65
BAX	biomarker_for	gene	0.65
CREB	biomarker_for	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROBLASTOMA in their description or question text

No additional research found