gene

ATG10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG10 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 117 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG10
Full Name	Autophagy Related 10
Chromosome	5q21.3
Protein Type	Enzyme
Function	encodes an E2-like conjugating enzyme that plays an essential role in the autophagy conjugation system.
Primary Expression	tissues throughout the body, with particularly important functions in neurons where autophagy is crucial for synaptic maintenance, mitochondrial quali
Molecular Weight	21 kDa
Amino Acids	182 aa
Pathways	Autophagy, Chaperone, Epigenetic, Mtor, Sod1
UniProt ID	[Q9Y4K0](https://www.uniprot.org/uniprot/Q9Y4K0)
Ensembl ID	ENSG00000138107
OMIM	610070
GeneCards	ATG10
Human Protein Atlas	ATG10
Associated Diseases	neurodegeneration
Interactions	LAMP1, STIP1, TREH, CTSB, MCOLN1, GLA
KG Connections	153 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG10["ATG10"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG10["ATG10"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ATG10["ATG10"] -->|"activates"| Ataxia["Ataxia"]
    ATG10["ATG10"] -->|"activates"| Als["Als"]
    ATG10["ATG10"] -->|"activates"| Parkinson["Parkinson"]
    ATG10["ATG10"] -->|"activates"| Huntington["Huntington"]
    TFEB["TFEB"] -->|"regulates"| ATG10["ATG10"]
    SQSTM1["SQSTM1"] -->|"participates in"| ATG10["ATG10"]
    STIP1["STIP1"] -->|"activates"| ATG10["ATG10"]
    LGALS3["LGALS3"] -->|"activates"| ATG10["ATG10"]
    style ATG10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (90)

Target	Relation	Type	Str
Cancer	biomarker_for	disease	0.90
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	activates	disease	0.65
Huntington	activates	disease	0.65
Neuroblastoma	activates	disease	0.65
Ms	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Spinocerebellar Ataxia	activates	disease	0.65
LAMP1	activates	gene	0.60
STIP1	activates	gene	0.60
TREH	activates	gene	0.60
CTSB	activates	gene	0.60
MCOLN1	activates	gene	0.60
ATF4	regulates	gene	0.60
WIPI2	expressed_in	gene	0.60
GLA	activates	gene	0.60
HSPA8	activates	gene	0.60
TARDBP	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
LGALS3	activates	gene	0.60
ATG12	activates	gene	0.60
BECN1	activates	gene	0.60
HSPB8	activates	gene	0.60
LAMP2A	activates	gene	0.60
TFEB	activates	gene	0.60
PPARGC1A	activates	gene	0.60
BAG3	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
BCL2	activates	gene	0.60
MTOR	activates	gene	0.60
TPP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
P62	activates	gene	0.60
SOD1	activates	gene	0.60
STUB1	activates	gene	0.60
PPP3CB	activates	gene	0.60
GAPDH	activates	gene	0.60
ATG12	regulates	entity	0.60
BAG3	regulates	entity	0.60
BECN1	regulates	entity	0.60
CTSB	regulates	entity	0.60
GLA	regulates	entity	0.60
HSPB8	regulates	entity	0.60
LAMP2A	regulates	entity	0.60

Incoming (63)

Source	Relation	Type	Str
TFEB	upregulates	protein	0.85
SQSTM1	participates_in	gene	0.80
DDX10	inhibits	gene	0.70
PTBP1	inhibits	gene	0.70
SIRT6	inhibits	gene	0.70
FAT1	inhibits	gene	0.70
SOX2	inhibits	gene	0.70
miR-369-3p	inhibits	entity	0.70
miR-100-3p	inhibits	entity	0.70
miR-27b-3p	inhibits	entity	0.70
miR-197-3p	inhibits	entity	0.70
let-7i-5p	inhibits	entity	0.70
miR-552	inhibits	entity	0.70
STIP1	activates	gene	0.60
LGALS3	activates	gene	0.60
HSPA8	activates	gene	0.60
MCOLN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SOD1	activates	gene	0.60
BCL2	activates	gene	0.60
CTSB	activates	gene	0.60
TPP1	activates	gene	0.60
GLA	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	activates	gene	0.60
PPARGC1A	activates	gene	0.60
TARDBP	activates	gene	0.60
TREH	activates	gene	0.60
BECN1	activates	gene	0.60
GAPDH	activates	gene	0.60
PPP3CB	activates	gene	0.60
HSPB8	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
BAG3	activates	gene	0.60
LAMP2A	activates	gene	0.60
TFEB	activates	gene	0.60
LAMP1	activates	gene	0.60
P62	activates	gene	0.60
ATG12	regulates	gene	0.60
EIF2A	activates	gene	0.60
CAT	regulates	gene	0.60
ATG3	regulates	gene	0.60
CLN3	expressed_in	gene	0.60
GABARAPL2	expressed_in	gene	0.60
SNX2	expressed_in	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60
PPP3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG10

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG10 Gene

Autophagy Mechanisms

Autophagy-Lysosomal Pathway

ATG7 Protein — Autophagy-Related Protein 7

Autophagy-Lysosome Pathway in Neurodegeneration

LAMP2A Protein — Lysosomal-Associated Membrane Protein 2A

Autophagy Molecular Regulation in Neurodegeneration

LAMP2A Gene

ATG7 Protein

ATG5 — Autophagy Related 5

snx2

ATG12 — Autophagy Related 12

Macroautophagy

atg16l1

LAMP2A Protein

ATG12 Protein (Autophagy-related Protein 12)

ATG5 Protein

ATG10 Protein

STUB1 — CHIP