entity

Huntington

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Huntington: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3682Connections
0Hypotheses
2Analyses
50Outgoing
50Incoming

Summary

Huntington is an entity related to neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 740 entities in the SciDEX knowledge graph.

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Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cholinergic Interneurons in Huntington Disease

cell · 1122 words

Novel Therapy Index

idea · 10647 words

Parkinson's Disease

disease · 8807 words

Parthanatos in Neurodegeneration

mechanism · 6619 words

calcium-dysregulation-comparison

mechanism · 6468 words

Therapeutics

index · 5665 words

Pathway Diagram

graph TD
    Huntington["Huntington"] -->|"interacts"| HTT["HTT"]
    Huntington["Huntington"] -->|"associated"| Mtor["Mtor"]
    Huntington["Huntington"] -->|"associated"| Autophagy["Autophagy"]
    Huntington["Huntington"] -->|"regulates"| Akt["Akt"]
    Huntington["Huntington"] -->|"regulates"| Pi3K["Pi3K"]
    Huntington["Huntington"] -->|"contributes to"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    HTT_1["HTT"] -->|"implicated in"| Huntington["Huntington"]
    HTT_2["HTT"] -->|"interacts"| Huntington["Huntington"]
    HTT_3["HTT"] -.->|"inhibits"| Huntington["Huntington"]
    STIP1["STIP1"] -->|"associated"| Huntington["Huntington"]
    style Huntington fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1829)

TargetRelationTypeStr
Alzheimerassociated_withdisease1.00
Parkinsonassociated_withdisease1.00
Neurodegenerationassociated_withdisease1.00
Mtoractivatespathway1.00
Neurodegenerationactivatesdisease1.00

Incoming (1853)

SourceRelationTypeStr
HUNTINGTON'S DISEASEassociated_withgene1.00
AUTOPHAGYactivatesgene1.00
NEURODEGENERATIVE DISEASEStherapeutic_targetgene1.00
NEURODEGENERATIONtherapeutic_targetgene1.00
NEURODEGENERATIVE DISEASESactivatesgene1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found