Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Huntington: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Huntington is an entity related to neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 740 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
Huntington["Huntington"] -->|"interacts"| HTT["HTT"]
Huntington["Huntington"] -->|"associated"| Mtor["Mtor"]
Huntington["Huntington"] -->|"associated"| Autophagy["Autophagy"]
Huntington["Huntington"] -->|"regulates"| Akt["Akt"]
Huntington["Huntington"] -->|"regulates"| Pi3K["Pi3K"]
Huntington["Huntington"] -->|"contributes to"| Blood_Brain_Barrier["Blood-Brain Barrier"]
HTT_1["HTT"] -->|"implicated in"| Huntington["Huntington"]
HTT_2["HTT"] -->|"interacts"| Huntington["Huntington"]
HTT_3["HTT"] -.->|"inhibits"| Huntington["Huntington"]
STIP1["STIP1"] -->|"associated"| Huntington["Huntington"]
style Huntington fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Alzheimer | implicated_in | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Aging | associated_with | disease | 0.95 |
| Oxidative Stress | therapeutic_target | pathway | 0.90 |
| Multiple Sclerosis | associated_with | disease | 0.85 |
| Als | implicated_in | disease | 0.85 |
| Parkinson | causes | disease | 0.85 |
| Alzheimer | causes | disease | 0.85 |
| Ataxia | associated_with | disease | 0.85 |
| Als | associated_with | disease | 0.85 |
| Parkinson | regulates | disease | 0.85 |
| Alzheimer | regulates | disease | 0.85 |
| Amyotrophic Lateral Sclerosis | causes | disease | 0.85 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Autophagy | therapeutic_target | pathway | 0.80 |
| Oxidative Stress | activates | pathway | 0.80 |
| Mitophagy | therapeutic_target | pathway | 0.80 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.80 |
| Autophagy | inhibits | pathway | 0.80 |
| Differentiation | regulates | pathway | 0.80 |
| Apoptosis | activates | pathway | 0.75 |
| Als | regulates | disease | 0.75 |
| Amyotrophic Lateral Sclerosis | implicated_in | disease | 0.75 |
| Parkinson | implicated_in | disease | 0.75 |
| Parkinson | contributes_to | disease | 0.75 |
| Als | inhibits | disease | 0.75 |
| Alzheimer | contributes_to | disease | 0.75 |
| Neurodegeneration | inhibits | disease | 0.75 |
| Stroke | associated_with | disease | 0.75 |
| Stroke | activates | disease | 0.75 |
| Neuroinflammation | therapeutic_target | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| Inflammation | implicated_in | disease | 0.75 |
| Amyotrophic Lateral Sclerosis | activates | disease | 0.75 |
| HTT | interacts_with | entity | 0.70 |
| Mtor | associated_with | pathway | 0.70 |
| Autophagy | associated_with | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| HUNTINGTON | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| PARKINSON | regulates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | causes | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| PARKINSON | causes | gene | 1.00 |
| HUNTINGTON | causes | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| HUNTINGTON | regulates | gene | 1.00 |
| HUNTINGTON | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | causes | gene | 1.00 |
| HUNTINGTON | implicated_in | gene | 1.00 |
| PARKINSON | implicated_in | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | implicated_in | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | activates | gene | 1.00 |
| MTOR | activates | gene | 0.95 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.95 |
| ALZHEIMER'S DISEASE | activates | gene | 0.95 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.95 |
| AGING | activates | gene | 0.95 |
| ALZHEIMER | contributes_to | gene | 0.95 |
| PARKINSON | contributes_to | gene | 0.95 |
| HUNTINGTON | contributes_to | gene | 0.95 |
| MITOCHONDRIA | regulates | gene | 0.95 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.95 |
| PARKINSON'S DISEASE | causes | gene | 0.95 |
| ALZHEIMER'S DISEASE | causes | gene | 0.95 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.95 |
| AUTOPHAGY | therapeutic_target | gene | 0.85 |
| MICROGLIA | activates | gene | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||