| Gene Symbol | IL |
| Full Name | 1β Protein — Interleukin-1 Beta |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| Subcellular Localization | </strong></td><td>Secreted, Cytoplasm</td></tr> |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Pro-domain | Maintains inactive conformation |
| Mature domain | Contains the receptor-binding interface |
| Beta-trefoil fold | Characteristic of IL-1 family proteins |
| No signal peptide | Secreted via unconventional pathway (inflammasome-dependent) |
| Inflammation initiation | Induces expression of adhesion molecules and chemokines |
| Fever induction | Acts on hypothalamus via IL-1R1 |
| Leukocyte recruitment | Promotes neutrophil and monocyte infiltration |
| Acute phase response | Stimulates liver to produce acute phase proteins |
| T cell activation | Co-stimulatory signal for Th1 responses |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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