protein 925 words KG: LRP12PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP12 Protein

🔬 Protein Info
Gene SymbolLRP12
Full NameLow Density Lipoprotein Receptor-Related Protein 12
AliasesST7, MIG13
Chromosome8q22.3
Protein TypeReceptor
Functionis a member of the LDL receptor family involved in lipoprotein metabolism, cell signaling, and synaptic function.
Primary Expressionvarious tissues, including brain regions critical for learning and memory [@lrpa]
Subcellular LocalizationCell surface, plasma membrane
Molecular Weight~250 kDa
Amino Acids2245 aa
UniProt IDQ9Y4F5
NCBI Gene ID50767
GeneCardsLRP12
Human Protein AtlasLRP12
Protein NameLow-Density Lipoprotein Receptor-Related Protein 12
Associated DiseasesAls, Alzheimer, Ms
KG Connections7 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 4 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses