protein 772 words KG: OPRK1 2026-03-14
kind:proteinsection:proteinsstate:published
Contents

Kappa-Opioid Receptor Protein

🔬 Protein Info
Gene SymbolOPRK1
AliasesKOR, OPRK
Chromosome8q11.23
Protein TypeReceptor
FunctionDynorphins are the only known endogenous ligands with significant KOR selectivity; beta-endorphin and enkephalins bind primarily to mu and delta receptors[@bruchas2011].
Primary ExpressionCNS (striatum, cortex, hippocampus, hypothalamus, spinal cord), peripheral sensory neurons, immune cells
Subcellular Localization</th><td>Plasma membrane, postsynaptic</td></tr>
Molecular Weight48 kDa
Amino Acids426 aa
PathwaysMAPK pathway, PI3K
UniProt IDP41145
NCBI Gene ID4985
GeneCardsOPRK1
Human Protein AtlasOPRK1
Associated DiseasesParkinson's disease, Alzheimer's disease
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in