protein 1,339 words KG: OXR1PROTEIN 2026-03-31
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

OXR1 Protein (Oxidoreductase NRD1)

🔬 Protein Info
Gene SymbolOXR1
Full NameOxidoreductase NRD1
AliasesOXR1PROTEIN
Chromosome8q23.3.
Protein TypeOxidoreductase
FunctionOXR1 is a conserved protein with oxidoreductase activity.
Primary Expressiondopaminergic neurons and is critical for their survival - oxidative stress: PD brains show increased oxidative markers; OXR1 deficiency exacerbat
Subcellular Localizationthe mitochondria and cytosol, where it plays crucial roles in oxidative stress resistance and mitochondrial function. OX
Molecular Weight73 kDa
Amino Acids660 aa
Exons17
PathwaysOxidative Stress
UniProt IDQ9C0A1
NCBI Gene ID55074
GeneCardsOXR1
Human Protein AtlasOXR1
Associated Diseasesneurodegeneration
InteractionsSTAT3, NRF2, HCRT, AND, NEURODEGENERATION, DMSO
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in