concept

HCRT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

291Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HCRT
Key Genes/Proteins	OX1, OX2, HCRTR1, HCRTR2
Related Diseases	Narcolepsy Type 1, Alcohol Use Disorder, Alcohol Drinking, Arousal Dysfunction

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HCRT["HCRT"]
    style HCRT fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HCRT -->|"activates"| Als["Als"]
    HCRT -->|"activates"| Ms["Ms"]
    HCRT -->|"target for"| Cardiovascular["Cardiovascular"]
    HCRT -->|"expressed in"| Aging["Aging"]
    HCRT -->|"implicated in"| neurodegeneration["neurodegeneration"]
    HCRT -->|"interacts"| HCRTR2([HCRTR2])
    HCRT -->|"interacts"| HCRTR1([HCRTR1])
    HCRT -->|"causes"| narcolepsy["narcolepsy"]
    h_6b84d8e2["h-6b84d8e2"] -->|"targets"| HCRT
    HCRTR2 -->|"regulates"| HCRT
    KCNQ2([KCNQ2]) -->|"regulates"| HCRT
    NEURON([NEURON]) -->|"expressed in"| HCRT
    AGING([AGING]) -->|"expressed in"| HCRT
    Neuropeptide_and_Endocrine_Sig["Neuropeptide and Endocrine Signaling in CBS/PSP"] -->|"references"| HCRT

Outgoing (172)

Target	Relation	Type	Str
OX1	activates	protein	0.95
OX2	activates	protein	0.95
Narcolepsy Type 1	implicated_in	disease	0.95
Crf Neurons	interacts_with	cell_type	0.95
HCRTR1	co_mentioned_with	gene	0.90
HCRTR2	co_mentioned_with	gene	0.90
Alcohol Use Disorder	implicated_in	disease	0.90
arousal regulation	mediates	process	0.90
Alcohol Drinking	regulates	phenotype	0.90
arousal state control	mediates	process	0.85
Arousal Dysfunction	regulates	phenotype	0.85
thalamus	expressed_in	brain_region	0.80
Sleep Regulation	involved_in	process	0.80
Blood Pressure Regulation	regulates	process	0.80
Hypertension	associated_with	disease	0.80
sleep disorders	associated_with	disease	0.70
neurons	associated_with	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Sleep Disorder	regulates	disease	0.65
Sleep Disorder	causes	disease	0.65
Addiction	associated_with	disease	0.65
Addiction	activates	disease	0.65
Addiction	regulates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Obesity	causes	disease	0.65
Dementia	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Autoimmune	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Aging	inhibits	disease	0.65
ALS	activates	disease	0.65
Anxiety	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Lewy Body	expressed_in	disease	0.65

Incoming (119)

Source	Relation	Type	Str
h-6b84d8e2	targets_gene	hypothesis	0.90
h-6b84d8e2	targets	hypothesis	0.80
HCRTR2	regulates	gene	0.60
KCNQ2	regulates	gene	0.60
HCRTR2	binds_to	protein	0.60
QRFP	biomarker_for	gene	0.60
TAU	expressed_in	gene	0.60
HCRTR2	expressed_in	gene	0.60
ACE	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR1	regulates	gene	0.60
CRH	causes	gene	0.60
OXR1	inhibits	gene	0.60
HCRTR1	activates	gene	0.60
HCRTR1	associated_with	gene	0.60
ACE	interacts_with	gene	0.60
NEURON	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEMENTIA	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
DNA	associated_with	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
RNA	associated_with	gene	0.60
NEURODEGENERATION	causes	gene	0.60
DMSO	inhibits	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ANXIETY	inhibits	gene	0.60
AND	causes	gene	0.60
PARKINSON	associated_with	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AND	stabilizes	gene	0.60
GENES	associated_with	gene	0.60
SLEEP-WAKE CYCLE	associated_with	gene	0.60
NEURON	causes	gene	0.60
C1Q	activates	gene	0.55
HCRTR2	interacts_with	gene	0.50
narcolepsy	causes	disease	0.50
narcolepsy	associated_with	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypocretin-Neurogenesis Coupling Therapy	0.452	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces [PMID:38123729]	Bandarabadi M, Li S, Aeschlimann L, Colo	Molecular psychiatry	2024	0
Fresh versus frozen embryo transfers in assisted reproduction. [PMID:33539543]	["Zaat T", "Zagers M", "Mol F", "Goddijn	The Cochrane database of syste	2021	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
Diabetic neuropathy. [PMID:31197153]	["Feldman E", "Callaghan B", "Pop-Busui	Nature reviews. Disease primer	2019	0
Views and experiences with regard to antibiotic use of hospitalized patients in [PMID:29777924]	["Zanichelli V", "Monnier A", "Tebano G"	Clinical microbiology and infe	2019	0
[ [PMID:30543234]	["Isaac-Oliv\u00e9 K", "Ocampo-Garc\u00e	Nanoscale	2019	0
Spatial and temporal heterogeneity of mouse and human microglia at single-cell r [PMID:30760929]	["Masuda T", "Sankowski R", "Staszewski	Nature	2019	0
Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. [PMID:29425372]	Olsson M, Ärlig J, Hedner J, Blennow K,	Sleep	2018	0
Human hippocampal neurogenesis drops sharply in children to undetectable levels [PMID:29513649]	["Sorrells S", "Paredes M", "Cebrian-Sil	Nature	2018	0
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Mod [PMID:29805100]	Borniger JC, Walker Ii WH, Surbhi, Emmer	Cell metabolism	2018	0
Environmental Surveillance of Norovirus Genogroups I and II for Sensitive Detect [PMID:28213546]	["Kazama S", "Miura T", "Masago Y", "Kon	Applied and environmental micr	2017	0
Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olso [PMID:28159567]	["Saer R", "Stadnytskyi V", "Magdaong N"	Biochimica et biophysica acta.	2017	0
Atmospheric pressure mass spectrometric imaging of live hippocampal tissue slice [PMID:29235455]	["Kim J", "Seo E", "Kim H", "Park J", "L	Nature communications	2017	0
Challenges in the development of therapeutics for narcolepsy. [PMID:26721620]	Black SW, Yamanaka A, Kilduff TS	Progress in neurobiology	2017	0
Animal model of Sar1b deficiency presents lipid absorption deficits similar to A [PMID:25559265]	["Levic D", "Minkel J", "Wang W", "Rybsk	Journal of molecular medicine	2015	0

HCRT

Understanding Entity Pages

Wiki Pages (20)

Orexin Neurons

Orexin/Hypocretin Signaling Pathway in Neurodegeneration

Amygdala

Brainstem Laterodorsal Tegmental Nucleus

Lateral Hypothalamus

Tyramine/Hypocretin Neurons

Orexin/Hypocretin Neurons

Narcolepsy

Lateral Hypothalamus in Arousal and Reward

Circadian-Glymphatic-Metabolic Coupling Failure Hypothesis in AD

Lateral Hypothalamic Area Neurons

Perifornical Orexin Neurons

Neuropeptide and Endocrine Signaling in CBS/PSP

Lateral Hypothalamus Orexin/Hypocretin Neurons

Orexin/Hypocretin Neurons

Orexin Neurons in Narcolepsy with Cataplexy

Orexin-1 Receptor Neurons

Thalamus

QRFP Gene