| Gene Symbol | PLK1PROTEIN |
| Chromosome | 16p12.1 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a serine/threonine kinase that functions as a master regulator of mitosis and cell cycle progression. |
| Primary Expression | differentiated neurons and regulates: |
| Subcellular Localization | suggests specialized functions at synapses beyond cell cycle regulation |
| Molecular Weight | 66 kDa |
| GeneCards | PLK1PROTEIN |
| Human Protein Atlas | PLK1PROTEIN |
| Centrosome maturation | Recruits gamma-tubulin ring complex (γTuRC) for microtubule nucleation |
| Spindle assembly | Promotes spindle pole organization and kinetochore-microtubule attachments |
| Metaphase-anaphase transition | Phosphorylates components of the APC/C complex |
| Cytokinesis | Recruits essential proteins to the midbody for abscission |
| Synaptic vesicle dynamics | Controls presynaptic vesicle cycling |
| Dendritic development | Regulates dendritic arborization and spine formation |
| Associated Diseases | ALS |
| Interactions | ALS, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, App, BUB1, CANCER |
| KG Connections | 89 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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