protein 666 words KG: PRIONPROTEIN
Contents

Prion Protein (PrP)

🔬 Protein Info
Gene SymbolPRIONPROTEIN
Full NamePrion (PrP)
Chromosome20p13.
Protein TypeProtein
Functionis a glycosylphosphatidylinositol (GPI)-anchored protein that plays a central role in prion diseases, also known as transmissible spongiform encephalopathies (TSEs).
Amino Acids23 aa
UniProt IDSearch UniProt
GeneCardsPRIONPROTEIN
Human Protein AtlasPRIONPROTEIN
Creutzfeldt-Jakob Disease (CJD)Primary human prion disease
Protein MisfoldingGeneral mechanism shared with other neurodegenerative diseases
Associated Diseasesneurodegeneration
InteractionsTAU
KG Connections29 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (12)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Netrin-1 Gradient Restoration
Score: 0.59
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (10)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability in CJD
clinical · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.