protein 948 words KG: ST6GALNAC5
Contents

St6galnac5 (ST6 N-acetylneuraminic acid alpha-2,6-sialyltransferase)

🔬 Protein Info
Gene SymbolST6GALNAC5
Full NameST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Chromosome1p31.3
Protein TypeSialyltransferase
FunctionSialylation of glycoproteins, neural cell adhesion
Primary ExpressionAstrocytes, brain
Subcellular Localizationthe Golgi apparatus where it sialylates target proteins destined for secretion or membrane presentation
UniProt IDQ9H0X9
NCBI Gene ID256297
Ensembl IDENSG00000160584
GeneCardsST6GALNAC5
Human Protein AtlasST6GALNAC5
Protein stability and half-lifeSialylated proteins are protected from degradation
Cell-cell recognitionSialic acid residues serve as ligands for siglecs and other lectins
Receptor-ligand interactionsSialylation modulates the affinity of various receptors
Associated DiseasesAlzheimer's disease
KG Connections5 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (3)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62

Related Analyses (4)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (6)

Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: debate_co_mention
Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: debate_co_mention
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: debate_co_mention
PARP1 Gene
gene · KG edge: debate_co_mention

Knowledge Graph (5 edges)

APOE debate_co_mention ST6GALNAC5
autophagy debate_co_mention ST6GALNAC5
neuroinflammation debate_co_mention ST6GALNAC5
PARP1 debate_co_mention ST6GALNAC5
ST6GALNAC5 debate_co_mention TREM2

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