| Gene Symbol | PARP1 |
| Aliases | Poly(ADP-ribose) polymerase 1, ADPRT, Poly(ADP-Ribose |
| Protein Family | PARP family (17 members) |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Upon DNA binding, PARP1 catalytic activity increases 500-fold, synthesizing PAR chains on itself (automodification) and target proteins[@benjamin1980]. |
| Mechanism of Action | Competitive inhibitors of PARP1 enzymatic activity blocking DNA repair |
| Subcellular Localization | ** Nucleus (primary), mitochondrial under stress |
| Druggability | Medium (0.62) |
| Clinical Stage | Approved |
| Molecular Weight | 113 kDa |
| Pathways | DNA repair, NAD+ metabolism, Apoptosis, NF-κB |
| UniProt ID | P09874 |
| GeneCards | PARP1 |
| Human Protein Atlas | PARP1 |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, AMI, ARM |
| Known Drugs/Compounds | OLAPARIB, PARP inhibitor, Parp Inhibitors, EMPAGLIFLOZIN, ANTHOCYANINS, TREHALOSE |
| Interactions | PEN2, PSEN1, DAPK1, HSPG2, IL1B, APP |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | PARP1 Inhibition Therapy PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Dam Oligodendrocyte DNA Repair Enhancement |
| KG Connections | 905 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |