protein 3,035 words KG: TARDNABINDINGPROTEIN43 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

TAR DNA-Binding Protein 43 (TDP-43)

🔬 Protein Info
Gene SymbolTDP-43
AliasesTARDNABINDINGPROTEIN43
Chromosome1p36.2
Protein FamilyHeterogeneous nuclear ribonucleoprotein (hnRNP) family
Subcellular LocalizationNucleus (physiological), cytoplasm (disease)
Molecular Weight43 kDa (414 amino acids)
PathwaysAmyloid Filaments, Cytoplasmic Accumulation, Isoaspartate Formation, NEURODEGENERATION, Nuclear Condensation
UniProt IDQ13148
GeneCardsTDP-43
Human Protein AtlasTDP-43
GeneTARDBP
PDB2N4P, 5E1O, 6N3T
Mol. Weight44.7 kDa (full-length), 43 kDa (cleaved)
Associated DiseasesALS, ALS-FTD, ALS/FTLD, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, AUTOPHAGY
Known Drugs/CompoundsUG-rich RNA sequences, RAPAMYCIN, RNA oligonucleotides, PROTAC, ASO, trehalose
InteractionsUBIQUITIN, STING, PINK1, CHMP2B, VALOSIN, OVERVIEW
KG Connections1679 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58
RNA Granule Nucleation Site Modulation
Score: 0.48
Arginine Methylation Enhancement Therapy
Score: 0.46

Related Analyses (16)

Epigenetic reprogramming in aging neurons
neurodegeneration · completed
What determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failed
How does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failed
What upstream mechanisms cause TDP-43 to trigger mPTP openin
neurodegeneration · failed
How do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed

Related Experiments (3)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.46
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.46
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.46

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in