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protein 935 words KG: TRANSFERRINRECEPTOR
Contents

Transferrin Receptor 1 (TFRC)

🔬 Protein Info
Gene SymbolTRANSFERRINRECEPTOR
AliasesTRANSFERRINRECEPTOR
Subcellular Localization</strong></td><td>Plasma membrane, Endosomes</td></tr>
Dimerization interfaceThe functional receptor is a disulfide-linked homodimer
Protease-like domainStructurally similar to carboxypeptidases
Helical domainContains the transferrin binding site
Apical domainModulates transferrin binding affinity
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (14)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Blood-Brain Barrier SPM Shuttle System
Score: 0.53Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inExosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypothesesLiquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypothesesMetabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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