| Gene Symbol | VGLUT1 |
| Aliases | Vesicular Glutamate Transporter 1 |
| Chromosome | 19q13.33 |
| Primary Expression | glutamatergic (excitatory) neurons |
| Molecular Weight | 62 kDa |
| Amino Acids | 560 aa |
| Exons | 12 |
| Pathways | Amyloid, Apoptosis |
| Ensembl ID | ENSG00000177656 |
| GeneCards | VGLUT1 |
| Human Protein Atlas | VGLUT1 |
| Substrate specificity | Highly selective for L-glutamate over L-aspartate, GABA, glycine |
| Km | ~1-2 mM for L-glutamate |
| Vmax | Dependent on V-ATPase activity and proton gradient |
| Copy number per vesicle | 5-12 VGLUT1 molecules per synaptic vesicle |
| Associated Diseases | ISCHEMIA, epilepsy, neurodegeneration |
| Interactions | TAU, APOE, APOE4, VEGF, GFAP, SLC17A6 |
| KG Connections | 197 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |